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| PRO-284 | 人血管抑素纖維蛋白溶酶原（rHuAng K1-3） | 20μg/100μg/1mg | Prospec |
| Background: | |
| Angiostatin was observed initially as an angiogenesis inhibitor, specifically inhibiting endothelial cell proliferation Recombinant angiostatin with one less kringle domain （kringle 1-3） acts as an effective inhibitor of angiogenesis induced by angiogenin , FGF basic, and VEGF | |
 | Description : |
| Recombinant Human Angiostatin produced in Pichia Pastoris is a single, non-glycosylated polypeptide chain having a molecular mass of 29711 Dalton. rHuAng K1-3 is a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. More active relative to kringles 1-4. rHuAng K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. Human Angiostatin is purified by proprietary chromatographic techniques. | |
| Physical Appearance: |
| Sterile Filtered liquid formulation. | |
| Formulation: |
| 1mg/ml containing 0.5X PBS. | |
| Stability: |
| Recombinant Human Angiostatin K1-3 should be stored at 40c. For long term storage it is recommended to add a carrier protein （ % HSA or BSA）. Please avoid freeze-thaw cycles. | |
| Purity: |
| Greater than 95.0% as determined by: （a） Analysis by RP-HPLC. （b） Anion-exchange FPLC. （c） Analysis by reducing and non-reducing SDS-PAGE Silver Stained. | |
| Dimers and aggregates: |
| Less than 1% as determined by silver-stained SDS-PAGE gel analysis. | |
| Biological Activity: |
| Inhibitory activity （ED50=70 nm） relative to Kringles 1-4 （ED50=135 nm）. Kringles 1-3 acts as inhibitor of endothelial cell growth and angiogenesis. | |
| Endotoxin: |
| Less than 0.1 ng/µg （IEU/µg） of Recombinant Angiostatin. | |
| Protein content: |
| Protein quantitation was carried out by two independent methods: 1. UV spectroscopy at 280 nm using the absorbency value of 2.08 as the extinction coefficient for a 0.1% （1mg/ml） solution. This value is calculated by the PC GENE computer analysis program of protein sequences （InliGenetics）. 2. Analysis by RP-HPLC, using a calibrated solution of Recombinant Angiostatin as a Reference Standard. | |
| Usage: |
| Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
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